Endocrine Abstracts

Introduction: Excess GH in acromegaly has lipolytic action and detrimental effect on glucose metabolism and insulin signaling. Recent studies have suggested a specific lipodystrophy in patients with acromegaly. Paradoxically, although the visceral adipose tissue (VAT) and intrahepatic lipid were reduced in active acromegaly compared to controls, insulin resistance was increased. Fat was redistributed from subcutaneous and visceral depots to muscle; weight and VAT depots rose w...

Background: Aryl hydrocarbon receptor-interacting protein (AIP) has been identified as a tumour suppressor gene in pituitary gland, causing 10% of all familial isolated pituitary adenoma. Patients with heterozygous loss-of-function germline mutation of AIP develop young-onset growth hormone and/or prolactin-secreting pituitary tumours. Homozygous loss of AIP leads to embryonic lethality in several animal models (mouse, fruit fly, round worm). Mouse e...

The impact of BMI, exercise, smoking, drug and alcohol use on reproductive and thyroid hormones has little or conflicting evidence. We therefore aimed to investigate the association between these factors and serum hormone concentrations. Capillary blood samples were taken from 932 eumenorrheic Hertility Health users on menstrual cycle day 3 between Sept 2020 and June 2022. Serum concentrations of Anti-Müllerian hormone, Estradiol (E2), Luteinising Hormone (LH), Follicle-S...

Background and aims: Thyroid peroxidase antibody (TPOAb) positivity is prevalent in women of reproductive age and pre-disposes to thyroid dysfunction, namely hypothyroidism, which has adverse effects on pregnancy. The aim of this study was to report the rate of development of abnormal thyroid function among initially euthyroid TPOAb positive women recruited into TABLET trial. To also identify factors associated with the development of hypothyroidism and to compare outcomes bet...

Thyroid hormone resistance syndrome(THRS) occurs in 1:40000 live births and can be diagnosed after a period of enigmatic changes in thyroid hormones(TH). Patients may be clinically euthyroid, have clinical hypo or hyperthyroidism. Mostly, it is an autosomal dominant disease due to germline mutations in THRβ-gene(exons 7-10). Resistance to peripheral action of TH leads to absence of TSH suppression (which can be normal/elevated) despite elevated fT4 and fT3.<p class="a...

Introduction: Testosterone-based gender-affirming hormone therapy (GAHT) may have negative consequences on cardiovascular risk, with reported increased blood pressure, decreased HDL-cholesterol, and weight gain. Still, data on cardiometabolic changes in transgender men on GAHT remain controversial. Testosterone-based GAHT also modifies body composition and lean muscle mass, but the degree to which affects serum creatinine and other measures of kidney function is still not clea...

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic condition which impairs enzymatic steroidogenesis of the adrenal cortex, leading to excessive androgen production. CAH phenotype is heterogeneous. In the mildest forms, it can present with hirsutism, acne and menstrual irregularities. Problems related to gender identification arise in about 5% of people with CAH with a 46,XX karyotype.Objective: We present the case of a young female-to-male ...

Introduction: Graves’ Orbitopathy (GO), the most common extrathyroidal manifestation of Graves’ disease (GD), usually presents bilateral disease. However, a minority of patients present with unilateral disease, the prevalence of which is between 4,5% and 14%. The aim of our study is to evaluate the specific demographic and clinical characteristics and potential differences between bilateral and unilateral GO, and the association with disease activity and severity.</p...

Introduction: Hyalinizing trabecular tumors are extremely rare and uncommon thyroid tumors, which were first described by Carney et al. Until now, their preoperative diagnosis based on cytological characteristics is not possible, because of the lack of specific features and molecular markers.Case presentation: We present a 38-year-old Caucasian female, non-smoker, with a disease-free medical history, with a right-sided clearly delimited large hy...

Introduction: Bilateral pheochromocytomas (PHEOs) most often occur as components of hereditary syndromes: MEN2A, VHL disease or neurofibromatosis. The best surgical technique in such cases is yet disputed between cortical sparing or total adrenalectomy. Two important complications are related to each surgical technique: adrenal insufficiency (AI) or recurrence-which one is more harmful for the patient?Aim: To evaluate the complications (recurrence, AI) r...